Depression And CBD – Cannabinoids And Mood

Depression And CBD

CBD is one of the most talked about cannabinoids in the headlines right now. Those who suffer from a wide variety of ailments, as well as the scientific community, are very interested in the effects of CBD. Depression and CBD could be a perfect match with natural hemp healing balancing the body.

We have seen CBD used for nausea and sore joints and learned the difference between CBD and THC. It is now time to take a look at how CBD can help with depression. Precisely why does it work? What exactly does using CBD for depression do?

Depression and CBD: What is CBD?

CBD is a compound in cannabis known as a cannabinoid. Cannabis is full of cannabinoids and science is finding that some work quite differently than others. THC works by binding to particular receptors in the brain that control coordination. Additionally, it governs short-term memory and one’s overall perception of reality. When THC attaches to the CB1 and CB2 receptors, it leads to intoxication.

CBD, on the contrary, operates in a far more advanced way, by altering some of the various other neurochemicals in the human brain. In particular, it keeps FAAH from doing its job. FAAH is a fatty acid which inhibits the uptake of organic endocannabinoids, CBD basically blocks FAAH, which leaves more of the feel-good endocannabinoids free to float around and do what they do best.

It also binds to CB1 receptors.

Depression and CBD: Why Does Treatment Work?

CBD impacts the chemistry in the brain in a couple of different ways detailed below.

Endocannabinoids And Mood

Science seems to agree that endocannabinoids regulate mood. Depression, anxiety, and PTSD benefit from endocannabinoid activity. These compounds are naturally a part of your body. When you consume additional CBD, you have boosted effectiveness.

This abundance of CBD elevates mood all by itself.

Serotonin also is involved in CBD’s mood-altering effects.

CBD And Serotonin

High levels of CBD can also stimulate serotonin receptors in the brain. One particular receptor, the 5-HT1A (hydroxytryptamine), controls a number of functions like anxiety, addiction, and sleep regulation. CBD slows down 5-HT1A’s uptake of serotonin which produces a relaxing effect.

Furthermore, CBD stimulates an additional part of the brain, referred to as Adenosine receptor.

The Adenosine Receptor and CBD

This particular receptor also is referred to as A2A. It works as an anti-inflammatory agent within the body and regulates the blood, oxygen, and circulation. Surprisingly enough, A2A also downregulates the secretion of dopamine as well as glutamate. Dopamine is a feel-good brain chemical which shows up when you are in love, when you consume a delicious meal, and even when you ingest some mind-altering drugs.

The Role Of PPARs

Peroxisome proliferator-activated receptors, or PPARs, regulate brain function. Decreased PPAR signaling contributes to psychotic effects associated with schizophrenia. Therefore, when PPAR is stimulated, it decreases inflammation within the body. It also decreases dopamine. Since CBD increases PPAR function, it restores the body’s natural balance and soothes signs or symptoms of several mood disorders.


Dopamine not only increases whenever we experience something we enjoy, it kicks in beforehand along with anticipation. This is the reason we experience a feeling of let down when we don’t get something we expect. This particular chemical comes into play when individuals gamble and do drugs. It actually releases at the simple sight of things we associate with the thing we want.

PTSD or schizophrenia are conditions where things get confusing. In these situations, dopamine increases during an episode or the onset of symptoms. A person could feel anxious, paranoid, and vigilant. Slowing down the dopamine uptake is really a good thing in these scenarios.

Depression and CBD: What It All Means…

The fundamental takeaway is the fact that CBD beneficially alters the chemical climate in the brain itself with no intoxicating effects. It is more of an organic boost. People that have difficulty with mood conditions like anxiety, depression, and PTSD could benefit from adding CBD to their routine.


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